The results also show that an alkaline pHe caused an elevation in SLP/OXPHOS ratio (approximately 98% SLP/OXPHOS) while the ratio was approximately 56% at neutral pHe and approximately 93% in acidic pHe. The findings show that the Warburg effect serves a functional role in regulating acidic pericellular p H (p He), which is mediated by metabolic inversion or a fluctuating dominance between glycolytic‐rate substrate level phosphorylation ( SLP) and mitochondrial ( mt) oxidative phosphorylation ( OXPHOS) to control lactic acid production. ![]() Using whole‐genome, proteomic MALDI‐ TOF‐ MS and metabolite analysis, we investigated the Warburg effect in malignant neuroblastoma N2a cells. A generally held notion is that the Warburg effect is related to energy. ![]() The Warburg effect describes a heightened propensity of tumor cells to produce lactic acid in the presence or absence of O 2.
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